The 90-year-old comedienne proved to be as sharp and naughty as ever.
She's been married three times.
Could Piers be number four?
Piers Morgan: My wife's last words to me tonight before I came down here were: "Watch yourself with Betty White." She said: "She's the ultimate cougar.
Betty White.: I am. I am. In my own head. Not anyplace else, but in my head, I'm the ultimate cougar. Animal lover that I am.
White is beset known for her roles on the Golden Girls and The Mary Tyler Moore Show.
She's won a slew of Emmys.
Her honors this year include a Screen Actors Guild Award for "Hot in Cleveland" and a Grammy for a spoken word album.