The crash occurred around 12:15 p.m. and involved a 2006 Ford Escape and a 2010 Chevy Colorado.
The Escape was traveling northbound while the Colorado was headed southbound. The driver of the Ford Escape crossed the center line into oncoming traffic and struck the Chevy head-on.
The driver of the SUV was pronounced dead at the scene, as well as two passengers in the pick-up truck.
All lanes of Route 158 were closed while the crash scene was cleared.