The Coast Guard says the victim has not been identified but say he was a Black male between the ages of 45 and 55.
St. Louis Fire Department crews searched for well over an hour last night after a 911 call came in about the man in the river.
Captain Sutter says the call came in right around 7:45 p.m. and St. Louis Fire Department crews searched with two boats until about 9:30 p.m. when it simply got too dark.
A helicopter was also brought in to help.
Sutter says fishermen spotted the man struggling in the river about two miles south of downtown. Investigators don`t` know how he ended up in the river. Sutter says crews did not find an overturned boat or a watercraft of some kind.
The fisherman actually tried to rescue the man themselves by throwing a line to him before fire crews got on the scene. But those attempts were unsuccessful.
Crews from the Mehlville and Columbia fire districts also assisted in the search last night.
This is the second time there has been trouble on the Mississippi in this area.
A man died on Wednesday after he and another man tried to rescue a family whose boat ran out of gas on the river on Tuesday. Everyone else in that case survived.
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Person Missing in Mississippi River